A subfamily of P-type ATPases with aminophospholip...[Science. 1996]

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1: Science. 1996 Jun 7;272(5267):1495-7. Links

Erratum in:: Science 1996 Dec 6;274(5293):1597.

A subfamily of P-type ATPases with aminophospholipid transporting activity.

Tang X, Halleck MS, Schlegel RA, Williamson P.

Department of Biology, Amherst College, MA 01002, USA.

The appearance of phosphatidylserine on the surface of animal cells triggers phagocytosis and blood coagulation. Normally, phosphatidylserine is confined to the inner leaflet of the plasma membrane by an aminophospholipid translocase, which has now been cloned and sequenced. The bovine enzyme is a member of a previously unrecognized subfamily of P-type adenosine triphosphatases (ATPases) that may have diverged from the primordial enzyme before the separation of the known families of ion-translocating ATPases. Studies in Saccharomyces cerevisiae suggest that aminophospholipid translocation is a general function of members of this family.

PMID: 8633245 [PubMed - indexed for MEDLINE]

Cloning, expression, and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase.
Biochem Biophys Res Commun. 1999 Apr 13; 257(2):333-9.

[Biochem Biophys Res Commun. 1999]
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.
Mol Biol Cell. 2003 Mar; 14(3):1240-54.

[Mol Biol Cell. 2003]
Protein-mediated inward translocation of phospholipids occurs in both the apical and basolateral plasma membrane domains of epithelial cells.
Biochemistry. 1999 Jan 5; 38(1):142-50.

[Biochemistry. 1999]
ReviewThe type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.
Biochim Biophys Acta. 2005 Jun 30; 1741(1-2):11-24.

[Biochim Biophys Acta. 2005]
ReviewOn the origin of lipid asymmetry: the flip side of ion transport.
Curr Opin Chem Biol. 2007 Dec; 11(6):654-61. Epub 2007 Nov 5.

[Curr Opin Chem Biol. 2007]
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Cited by 41 PubMed Central articles

An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases.
Lyssenko NN, Miteva Y, Gilroy S, Hanna-Rose W, Schlegel RA. BMC Dev Biol. 2008 Oct 2; 8:96. Epub 2008 Oct 2.

[BMC Dev Biol. 2008]
Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance.
Park SY, Kim SY, Jung MY, Bae DJ, Kim IS. Mol Cell Biol. 2008 Sep; 28(17):5288-98. Epub 2008 Jun 23.

[Mol Cell Biol. 2008]
P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes.
Liu K, Surendhran K, Nothwehr SF, Graham TR. Mol Biol Cell. 2008 Aug; 19(8):3526-35. Epub 2008 May 28.

[Mol Biol Cell. 2008]
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