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Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures.
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037, USA.
Alkaline phosphatase activity is present in the mesoderm of embryonic chick skin and becomes spatially restricted to the dermal condensation of the developing feather germs. Inhibitors to tissue-nonspecific (liver/bone/kidney), but not intestinal alkaline phosphatase inhibit the establishment and growth of feather germs in cultured skins. A window of maximum sensitivity to the inhibitor was observed to be the first day of culture when early development and establishment of pattern takes place. The cDNA for the avian tissue-nonspecific alkaline phosphatase was cloned and sequenced, and Southern analysis revealed a single copy of this gene in the avian genome. Northern analysis revealed that a 2.8 kb transcript for this form of alkaline phosphatase is present in developing skin.
PMID: 8563025 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Conservation of early odontogenic signaling pathways in Aves.
Chen Y, Zhang Y, Jiang TX, Barlow AJ, St Amand TR, Hu Y, Heaney S, Francis-West P, Chuong CM, Maas R.
Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10044-9.
[Proc Natl Acad Sci U S A. 2000]
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A novel Drosophila alkaline phosphatase specific to the ellipsoid body of the adult brain and the lower Malpighian (renal) tubule.
Yang MY, Wang Z, MacPherson M, Dow JA, Kaiser K.
Genetics. 2000 Jan; 154(1):285-97.
[Genetics. 2000]