Increase in the level of mRNA for 3-hydroxyanthran...[Biosci Biotechnol Biochem. 1995]

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1: Biosci Biotechnol Biochem. 1995 Nov;59(11):2191-2.Links

Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.

Nakagawa Y, Asai H, Kitoh J, Mori H, Nakano K.

Nagoya University Graduate School of Agriculture, Japan.

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

PMID: 8541664 [PubMed - indexed for MEDLINE]

Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice.
Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):132-7.

[Brain Res Mol Brain Res. 1998]
Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
Brain Res. 1992 Feb 14; 572(1-2):1-4.

[Brain Res. 1992]
Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase.
J Biol Chem. 1994 May 13; 269(19):13792-7.

[J Biol Chem. 1994]
ReviewKynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis.
Adv Exp Med Biol. 1996; 398:485-92.

[Adv Exp Med Biol. 1996]
ReviewRegulation of quinolinic acid synthesis by mitochondria and o-methoxybenzoylalanine.
Adv Exp Med Biol. 1999; 467:233-9.

[Adv Exp Med Biol. 1999]
» See reviews... | » See all...

Cited by 1 PubMed Central article

Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC. Appl Environ Microbiol. 2003 Mar; 69(3):1564-72.

[Appl Environ Microbiol. 2003]

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Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.

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