Clavulanic acid biosynthesis in Streptomyces clavu...[Gene. 1995]

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1: Gene. 1995 Dec 1;166(1):49-55. Links

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

Hodgson JE, Fosberry AP, Rawlinson NS, Ross HN, Neal RJ, Arnell JC, Earl AJ, Lawlor EJ.

SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.

Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.

PMID: 8529893 [PubMed - indexed for MEDLINE]

Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis.
Gene. 1994 Sep 15; 147(1):41-6.

[Gene. 1994]
Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production.
J Bacteriol. 1992 Jul; 174(14):4606-13.

[J Bacteriol. 1992]
Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.
Antimicrob Agents Chemother. 2004 Feb; 48(2):514-20.

[Antimicrob Agents Chemother. 2004]
ReviewBiosynthesis and molecular genetics of clavulanic acid.
Antonie Van Leeuwenhoek. 1999 Jan-Feb; 75(1-2):125-33.

[Antonie Van Leeuwenhoek. 1999]
ReviewClavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics.
Appl Microbiol Biotechnol. 2000 Oct; 54(4):467-75.

[Appl Microbiol Biotechnol. 2000]
» See reviews... | » See all...

Cited by 12 PubMed Central articles

Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus.
Zelyas NJ, Cai H, Kwong T, Jensen SE. J Bacteriol. 2008 Dec; 190(24):7957-65. Epub 2008 Oct 17.

[J Bacteriol. 2008]
Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.
de la Fuente A, Martín JF, Rodríguez-García A, Liras P. J Bacteriol. 2004 Oct; 186(19):6501-7.

[J Bacteriol. 2004]
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
Elkins JM, Kershaw NJ, Schofield CJ. Biochem J. 2005 Jan 15; 385(Pt 2):565-73.

[Biochem J. 2005]
» See all...

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Cited by 12 PubMed Central articles

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