- Comment in:
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Nat Genet. 1993 Jun;4(2):114-5.
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Nat Genet. 1993 May;4(1):7-8.
A molecular variant of angiotensinogen associated with preeclampsia.
Ward K,
Hata A,
Jeunemaitre X,
Helin C,
Nelson L,
Namikawa C,
Farrington PF,
Ogasawara M,
Suzumori K,
Tomoda S, et al.
Department of Obstetrics and Gynecology, University of Utah, School of Medicine, Salt Lake City 84132.
Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.
PMID: 8513325 [PubMed - indexed for MEDLINE]