Partial structure of the gene encoding the 78 kDa ...[Biochem Biophys Res Commun. 1993]

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1: Biochem Biophys Res Commun. 1993 Jun 15;193(2):560-4. Links

Partial structure of the gene encoding the 78 kDa gastrin binding protein excludes a close relationship with the peroxisomal trifunctional enzyme.

Baldwin GS, Casey A, Weinstock J.

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.

A 10.9 kb porcine genomic clone encoding nucleotides 124-732 of the cDNA for the porcine 78 kDa gastrin-binding protein has been isolated and characterized. The coding sequence is interrupted by 7 introns, which vary in length from 93 to 3000bp. The positions of the intron/exon junctions are different from the junctions in the gene encoding the rat peroxisomal trifunctional enzyme. Despite 33% amino acid sequence identity between the two proteins it is concluded that the porcine gastrin binding protein is not closely related to the rat trifunctional enzyme.

PMID: 8512557 [PubMed - indexed for MEDLINE]

Nucleotide sequence encoding a novel member of the hydratase/dehydrogenase family.
Biochim Biophys Acta. 1993 Oct 13; 1170(2):211-5.

[Biochim Biophys Acta. 1993]
Structures of the human cDNA and gene encoding the 78 kDa gastrin-binding protein and of a related pseudogene.
Biochim Biophys Acta. 1994 Oct 18; 1219(2):567-75.

[Biochim Biophys Acta. 1994]
Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA isomerase, 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase enzyme in rat liver. The proposed occurrence of isomerization and hydration in the same catalytic domain of the multifunctional enzyme.
J Biol Chem. 1991 Jun 15; 266(17):10750-3.

[J Biol Chem. 1991]
ReviewUnique multifunctional HSD17B4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome.
J Mol Endocrinol. 1999 Jun; 22(3):227-40.

[J Mol Endocrinol. 1999]
ReviewMolecular basis of D-bifunctional protein deficiency.
Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):61-70.

[Mol Cell Endocrinol. 2001]
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Cited by 1 PubMed Central article

Antiproliferative gastrin/cholecystokinin receptor antagonists target the 78-kDa gastrin-binding protein.
Baldwin GS. Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7593-7.

[Proc Natl Acad Sci U S A. 1994]

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Partial structure of the gene encoding the 78 kDa gastrin binding protein excludes a close relationship with the peroxisomal trifunctional enzyme.

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