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Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.
Van Leuven F,
Stas L,
Raymakers L,
Overbergh L,
De Strooper B,
Hilliker C,
Lorent K,
Fias E,
Umans L,
Torrekens S, et al.
Experimental Genetics Section, Katholieke Universiteit van Leuven, Belgium.
We have molecularly cloned and sequenced the mouse alpha-2-macroglobulin receptor cDNA. The cDNA contained 14849 bases with one large open reading frame of 4545 codons which is one more than in the corresponding human cDNA. Comparison of the predicted mouse and human receptor proteins revealed the very conserved nature of this receptor with an overall amino acid identity of more than 97%. A dramatic example of this is the presence of 331 cysteine residues predicted in the mouse protein, of which 327 are positionally conserved relative to human.
PMID: 8485155 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing.
Cheng CF, Fan J, Fedesco M, Guan S, Li Y, Bandyopadhyay B, Bright AM, Yerushalmi D, Liang M, Chen M, et al.
Mol Cell Biol. 2008 May; 28(10):3344-58. Epub 2008 Mar 10.
[Mol Cell Biol. 2008]
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Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice.
Teesalu T, Hinkkanen AE, Vaheri A.
Am J Pathol. 2001 Dec; 159(6):2227-37.
[Am J Pathol. 2001]