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1: Mol Biochem Parasitol. 1993 Jan;57(1):47-54.Click here to read Links

Crithidia fasciculata contains a transcribed leishmanial surface proteinase (gp63) gene homologue.

Inverso JA, Medina-Acosta E, O'Connor J, Russell DG, Cross GA.

Laboratory of Molecular Parasitology, Rockefeller University, New York, NY 10021.

We have cloned and analysed a gene from the insect parasite, Crithidia fasciculata, with homology to the gp63 metalloendoproteinase gene of Leishmania. The Crithidia gene homologue is arranged as a multicopy family comprised of approximately 7 genes. The mature transcript is 4.0 kb. The predicted amino acid sequence has significant homology with Leishmania gp63s, contains a zinc-binding motif and a potential site for addition of a glycosylphosphatidylinositol anchor. Demonstration of a gp63 homologue in C. fasciculata, a monogenetic parasite, suggests that the molecule may play a role in parasite survival within the insect gut.

PMID: 8426615 [PubMed - indexed for MEDLINE]