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Science. 1993 Jul 23;261(5120):428-9.
Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.
Department of Molecular Biology, Princeton University, NJ 08540.
A human gene encoding the c-myc purine-binding transcription factor PuF was identified by screening of a cervical carcinoma cell complementary DNA library with a DNA fragment containing PuF binding sites. The 17-kilodalton bacterially produced PuF was shown to have biological activity and properties similar to that of human PuF. DNA sequence analysis of recombinant PuF revealed perfect identity with the human nm23-H2 nucleoside diphosphate kinase gene, a potential negative regulator of cancer metastasis. These results provide a link between nm23 and the c-myc oncogene and suggest that the nm23 protein can function in vitro in the transcriptional regulation of c-myc expression.
PMID: 8392752 [PubMed - indexed for MEDLINE]
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Cited by 46 PubMed Central articles
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Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1.
Mochizuki T, Bilitou A, Waters CT, Hussain K, Zollo M, Ohnuma S.
Neural Dev. 2009 Jan 5; 4:1. Epub 2009 Jan 5.
[Neural Dev. 2009]
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Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression.
Thakur RK, Kumar P, Halder K, Verma A, Kar A, Parent JL, Basundra R, Kumar A, Chowdhury S.
Nucleic Acids Res. 2009 Jan; 37(1):172-83. Epub 2008 Nov 25.
[Nucleic Acids Res. 2009]
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The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant.
Nordman J, Wright A.
Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10197-202. Epub 2008 Jul 10.
[Proc Natl Acad Sci U S A. 2008]
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