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Molecular characterization of rat transforming growth factor-beta type II receptor.
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.
A cDNA encoding the rat transforming growth factor-beta (TGF-beta) type II receptor was isolated by hybridization from a rat pituitary gland cDNA library. The rat TGF-beta type II receptor comprises 567 amino acid residues with a cysteine-rich extracellular domain, a single transmembrane domain and an intracellular protein kinase domain with predicted serine/threonine specificity. The comparison of the amino acid sequences of the rat and human TGF-beta type II receptors indicated that they are highly conserved particularly in the intracellular kinase domain. RNA blot hybridization and reverse-transcription polymerase chain reaction (RT-PCR) analyses showed that rat TGF-beta type II receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung.
PMID: 8385453 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.
Tsuchida K, Mathews LS, Vale WW.
Proc Natl Acad Sci U S A. 1993 Dec 1; 90(23):11242-6.
[Proc Natl Acad Sci U S A. 1993]
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Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.
Koenig BB, Cook JS, Wolsing DH, Ting J, Tiesman JP, Correa PE, Olson CA, Pecquet AL, Ventura F, Grant RA.
Mol Cell Biol. 1994 Sep; 14(9):5961-74.
[Mol Cell Biol. 1994]
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Mapping of the ligand binding domain of the transforming growth factor beta receptor type III by deletion mutagenesis.
Pepin MC, Beauchemin M, Plamondon J, O'Connor-McCourt MD.
Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):6997-7001.
[Proc Natl Acad Sci U S A. 1994]
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