Crystal structure of the HhaI DNA methyltransferas...[Cell. 1993]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Cell. 1993 Jul 30;74(2):299-307. Links

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ.

W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, New York 11724.

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

PMID: 8343957 [PubMed - indexed for MEDLINE]

Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
Nucleic Acids Res. 2001 Jan 15; 29(2):439-48.

[Nucleic Acids Res. 2001]
Homology modelling of the DNA 5mC methyltransferase M.BssHII. Is permutation of functional subdomains common to all subfamilies of DNA methyltransferases?
Int J Biol Macromol. 2000 Jun 13; 27(3):195-204.

[Int J Biol Macromol. 2000]
Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment.
Nucleic Acids Res. 1997 Jul 15; 25(14):2702-15.

[Nucleic Acids Res. 1997]
ReviewStructure, function, and mechanism of HhaI DNA methyltransferases.
Crit Rev Biochem Mol Biol. 2002; 37(3):167-97.

[Crit Rev Biochem Mol Biol. 2002]
ReviewStructure and function of DNA methyltransferases.
Annu Rev Biophys Biomol Struct. 1995; 24:293-318.

[Annu Rev Biophys Biomol Struct. 1995]
» See reviews... | » See all...

Cited by 79 PubMed Central articles

Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Suzuki Y, Noma A, Suzuki T, Ishitani R, Nureki O. Nucleic Acids Res. 2009 May; 37(9):2910-25. Epub 2009 Mar 14.

[Nucleic Acids Res. 2009]
A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding.
Frauer C, Leonhardt H. Nucleic Acids Res. 2009 Feb; 37(3):e22. Epub 2009 Jan 7.

[Nucleic Acids Res. 2009]
Specific targeting of cytosine methylation to DNA sequences in vivo.
Smith AE, Ford KG. Nucleic Acids Res. 2007; 35(3):740-54. Epub 2006 Dec 20.

[Nucleic Acids Res. 2007]
» See all...

Structures reported by this article

Crystal Structure Of The Hhal Dna Methyltransferase Complexed With S-Adenosyl-L-Methionine

PDB: 1HMY

Source: Haemophilus haemolyticus

Method: X-Ray Diffraction | Resolution: 2.5 Å

Recent Activity

Clear Turn Off Turn On

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine...Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

Related articles

Cited by 79 PubMed Central articles

Structures reported by this article

Recent Activity