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1: Comp Biochem Physiol B. 1993 Nov;106(3):601-11.Links

Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers.

Ogawa H, Gomi T, Fujioka M.

Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.

1. Human liver contains a rather high level of glycine N-methyltransferase. 2. The enzymes from human, rat, rabbit and pig livers are all tetramers and exhibit positive cooperativity toward S-adenosylmethionine and Michaelis-Menten kinetics toward glycine. The [S]0.5 values for S-adenosylmethionine and glycine of the rat enzyme are considerably lower than those of three other enzymes. 3. The subunit of rat glycine N-methyltransferase is shorter by two residues compared with the subunits of human, rabbit and pig glycine N-methyltransferases. Except for this difference, however, all enzymes show a high degree of sequence homology.

PMID: 8281755 [PubMed - indexed for MEDLINE]