-
- Erratum in:
- Nat Genet 1994 Feb;6(2):214.
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Wistar Institute, Philadelphia, Pennsylvania 19104.
We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma. The chromosome 13 gene (FKHR) is identified as a member of the fork head domain family of transcription factors characterized by a conserved DNA binding motif. Polymerase chain reaction analysis demonstrates that a 5'PAX3-3' FKHR chimaeric transcript is expressed in all eight alveolar rhabdomyosarcomas investigated. Immunoprecipitation experiments detect the predicted fusion protein. These findings indicate that the t(2;13) generates a potentially tumorigenic fusion transcription factor consisting of intact PAX3 DNA binding domains, a truncated fork head DNA binding domain and C-terminal FKHR regions.
PMID: 8275086 [PubMed - indexed for MEDLINE]
-
Cited by 77 PubMed Central articles
-
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment.
Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, Yu Y, Zhou W, Li L, Feng J, et al.
Neoplasia. 2009 Apr; 11(4):313-24.
[Neoplasia. 2009]
-
Identification and analysis of evolutionary selection pressures acting at the molecular level in five forkhead subfamilies.
Fetterman CD, Rannala B, Walter MA.
BMC Evol Biol. 2008 Sep 24; 8:261. Epub 2008 Sep 24.
[BMC Evol Biol. 2008]
-
Molecular alterations in pediatric sarcomas: potential targets for immunotherapy.
Goletz TJ, Mackall CL, Berzofsky JA, Helman LJ.
Sarcoma. 1998; 2(2):77-87.
[Sarcoma. 1998]
- » See all...