Modulation of calmodulin plasticity in molecular r...[Science. 1993]

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1: Science. 1993 Dec 10;262(5140):1718-21. Links

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Meador WE, Means AR, Quiocho FA.

Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.

Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

PMID: 8259515 [PubMed - indexed for MEDLINE]

Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism.
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[Biochemistry. 1996]
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ReviewNeuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.
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[Annu Rev Biochem. 2002]
ReviewMolecular and structural basis of target recognition by calmodulin.
Annu Rev Biophys Biomol Struct. 1995; 24:85-116.

[Annu Rev Biophys Biomol Struct. 1995]
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Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
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Structures reported by this article

Crystal Structure Of Bovine Brain Ca++ Calmodulin In A Compact Form

PDB: 1PRW

Source: Bos taurus

Method: X-Ray Diffraction | Resolution: 1.7 Å
» See all 4 structures...

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