Structure of the glycosyl-phosphatidylinositol mem...[Biochem J. 1993]

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1: Biochem J. 1993 Dec 1;296 ( Pt 2):473-9. Links

Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica.

Mehlert A, Varon L, Silman I, Homans SW, Ferguson MA.

Department of Biochemistry, University of Dundee, Scotland, U.K.

The structure of the glycan moiety of the glycosyl-phosphatidylinositol (GPI) membrane anchor from Torpedo californica (electric fish) electric-organ acetylcholinesterase was solved using n.m.r., methylation analysis and chemical and enzymic micro-sequencing. Two structures were found to be present: Glc alpha 1-2Man alpha 1-2Man alpha 1-6Man alpha 1-4GlcN alpha 1-6myo-inositol and Glc alpha 1-2Man alpha 1-2Man alpha 1-6(GalNAc beta 1-4)Man alpha 1-4GlcN alpha 1-6myo-inositol. The presence of glucose in this GPI anchor structure is a novel feature. The anchor was also shown to contain 2.3 residues of ethanolamine per molecule.

PMID: 8257440 [PubMed - indexed for MEDLINE]

PMCID: PMC1137719

Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica.
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Cited by 4 PubMed Central articles

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[Biochem J. 1996]
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