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1: Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5490-4.Click here to read Links

Structure and cell cycle-regulated transcription of the human cyclin A gene.

Henglein B, Chenivesse X, Wang J, Eick D, Bréchot C.

Institut National de la Santé et de la Recherche Médicale, Unité 370, Institut Necker, Paris, France.

Cyclin A is a cell cycle regulatory protein that functions in mitotic and S-phase control in mammalian somatic cells. Its deregulated expression may have a role in cellular transformation. We have cloned and sequenced the human cyclin A gene and cDNAs representing its mRNAs and have characterized its promoter. Using synchronized cultures of NIH 3T3 cells stably transfected with cyclin A promoter/luciferase constructs, we show that the promoter is repressed during the G1 phase of the cell cycle and is activated at S-phase entry. Cell cycle regulation of the cyclin A gene promoter is mediated by sequences extending from -79 to +100 relative to the predominant transcription start site. It does not require the presence of a functional retinoblastoma protein.

PMID: 8202514 [PubMed - indexed for MEDLINE]

PMCID: PMC44021