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A mouse TGF-beta type I receptor that requires type II receptor for ligand binding.
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.
PMID: 8117262 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Embryonic stem cells can form germ cells in vitro.
Toyooka Y, Tsunekawa N, Akasu R, Noce T.
Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11457-62. Epub 2003 Sep 22.
[Proc Natl Acad Sci U S A. 2003]
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Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.
Larsson J, Goumans MJ, Sjöstrand LJ, van Rooijen MA, Ward D, Levéen P, Xu X, ten Dijke P, Mummery CL, Karlsson S.
EMBO J. 2001 Apr 2; 20(7):1663-73.
[EMBO J. 2001]
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Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching.
Joseph H, Gorska AE, Sohn P, Moses HL, Serra R.
Mol Biol Cell. 1999 Apr; 10(4):1221-34.
[Mol Biol Cell. 1999]
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