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LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains.
German Cancer Research Center, Heidelberg.
We here report the sequence of a yeast gene LRG1 whose deduced amino acid sequence contains sequence motifs similar to LIM domain proteins in the amino-terminal, and to rho/rac GTPase activating proteins (rho/racGAP's) in the carboxy-terminal part. LRG1 expression is differentially regulated showing a peak of expression in sporulating cells. Gene disruption experiments indicate that the gene is not essential and may play a role during mating.
PMID: 8065929 [PubMed - indexed for MEDLINE]
PMCID: PMC310289
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Cited by 8 PubMed Central articles
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[Eukaryot Cell. 2007]
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Lrg1p Is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast.
Fitch PG, Gammie AE, Lee DJ, de Candal VB, Rose MD.
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[Genetics. 2004]
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Gao XD, Caviston JP, Tcheperegine SE, Bi E.
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[Mol Biol Cell. 2004]
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