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1: FEBS Lett. 1994 Nov 21;355(1):19-22.Click here to read Links

Cloning of an isoform of mouse TGF-beta type II receptor gene.

Suzuki A, Shioda N, Maeda T, Tada M, Ueno N.

Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.

A variant of transforming growth factor-beta type II receptor (TGF-beta RII) cDNA was isolated from a mouse brain cDNA library. The predicted receptor is identical to previously reported mouse TGF-beta RII except that the isoform has an insertion sequence of 25 amino acids in the predicted ligand-binding domain. By the use of reverse transcription-polymerase chain reaction (RT-PCR), transcripts for both isoforms were detected in all tissues and developing embryos examined. The isoform transiently expressed in COS cells showed a similar ligand-binding specificity to authentic TGF-beta RII. These results suggest that the mouse TGF-beta RII gene generates multiple isoforms, possibly by alternative splicing, as reported for activin type IIB receptor; and an isoform which has the extra sequence in the ligand-binding domain is also involved in the TGF-beta signal transduction.

PMID: 7957954 [PubMed - indexed for MEDLINE]