Divergent sequences in the 5' region of cDNA sugge...[Biochem J. 1994]

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1: Biochem J. 1994 Oct 1;303 ( Pt 1):37-41. Links

Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

Corti O, DiDonato S, Finocchiaro G.

Istituto Nazionale Neurologico C. Besta, Divisione di Biochimica e Genetica, Milano, Italia.

We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA lambda SM-1400 extends the sequence of peroxisomal CAT, whereas cDNA lambda SM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.

PMID: 7945262 [PubMed - indexed for MEDLINE]

PMCID: PMC1137553

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Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

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