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1: Biochim Biophys Acta. 1994 Oct 21;1227(1-2):101-4.Links

Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes.

Miyazaki I, Gaedigk R, Hui MF, Cheung RK, Morkowski J, Rajotte RV, Dosch HM.

Hospital for Sick Children, Department of Paediatrics, University of Toronto, Ontario, Canada.

Triggering of autoimmunity in insulin-dependent diabetes was linked to dietary bovine serum albumin (BSA). Anti-BSA antibodies from diabetes-prone rats precipitate a protein, p69, from islet cell lysates. We have used these antibodies to identify rat p69 cDNAs. Human p69 cDNA was identified by crosshybridization. The p69 coding regions show 87% nucleotide and 89% amino acid homology. Recombinant p69 is recognized by autoantibody and T cells from diabetic children.

PMID: 7918678 [PubMed - indexed for MEDLINE]