Primary structure of a folate-dependent trifunctio...[Biochim Biophys Acta. 1995]

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1: Biochim Biophys Acta. 1995 Mar 14;1261(1):129-33.Links

Primary structure of a folate-dependent trifunctional enzyme from Spodoptera frugiperda.

Tremblay GB, MacKenzie RE.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

The dehydrogenase and synthetase activities of the NADP-dependent methylenetetra-hydrofolate dehydrogenase-cyclohydrolase-synthetase are undetectable in extracts of the Spodoptera frugiperda cell line, Sf9. However, a single cDNA encoding this protein was isolated from a library and sequenced. The deduced amino acid sequence codes for a protein of 933 amino acids in length that shows 59% identity to the human enzyme. The cDNA inserted in the yeast expression vector pVT102-U complements a purine auxotrophic yeast strain lacking this enzyme.

PMID: 7893749 [PubMed - indexed for MEDLINE]

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J Biol Chem. 2003 Oct 31; 278(44):43178-87. Epub 2003 Aug 22.

[J Biol Chem. 2003]
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[Biochem Biophys Res Commun. 2004]
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[J Biol Chem. 1988]
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[Arch Biochem Biophys. 2002]
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[Vitam Horm. 2008]
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