Your browser version may not work well with NCBI's Web applications. More information here...
1: FEMS Microbiol Lett. 1995 Aug 1;130(2-3):221-9.Links

The gene encoding the biotin-apoprotein ligase of Saccharomyces cerevisiae.

Cronan JE Jr, Wallace JC.

Department of Microbiology, University of Illinois, Urbana 6180, USA.

We report the isolation, genomic mapping, and DNA sequence of the BPL1 gene encoding the biotin-apoprotein ligase of Saccharomyces cerevisiae. The gene was isolated by complementation of an Escherichia coli birA (biotin-apoprotein ligase) mutant indicating that the expressed yeast protein modified the essential biotinated protein of the bacterial host. The BPL1 gene encodes a protein of 690 residues (M(r) 76.4 kDa) with strong sequence similarities to the E. coli and human biotin-apoprotein ligases. BPL1 was mapped to chromosome IV, is allelic to the previously described ACC2 gene, and encodes the major (if not the only) biotin-apoprotein ligase activity of S. cerevisiae.

PMID: 7649444 [PubMed - indexed for MEDLINE]