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The human gene encoding the largest subunit of RNA polymerase II.
Division of Biology, National Institute of Radiological Sciences, Chiba, Japan.
The nucleotide sequence of a large portion of the human RNA polymerase II large subunit (RpII LS)-encoding gene and its whole gene structure were determined. The RpIILS gene consists of 29 exons. The sequence of the 5' flanking region is highly conserved as compared with that of the mouse RpIILS and contains several SP1-binding sites, a CCAAT sequence and a sequence homologous to a heat-shock element. In addition, several inverted repeats and palindrome sequences were involved in the 5' upstream region. Those suggest that the 5' flanking domain of RpIILS would be highly structured which may be responsible for transcriptional regulation.
PMID: 7622068 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells.
Uzbekova S, Roy-Sabau M, Dalbiès-Tran R, Perreau C, Papillier P, Mompart F, Thelie A, Pennetier S, Cognie J, Cadoret V, et al.
Reprod Biol Endocrinol. 2006 Mar 21; 4:12. Epub 2006 Mar 21.
[Reprod Biol Endocrinol. 2006]
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A human RNA polymerase II subunit is encoded by a recently generated multigene family.
Grandemange S, Schaller S, Yamano S, Du Manoir S, Shpakovski GV, Mattei MG, Kedinger C, Vigneron M.
BMC Mol Biol. 2001; 2:14. Epub 2001 Nov 30.
[BMC Mol Biol. 2001]