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41 kilobases of analyzed sequence from the pseudoautosomal and sex-determining regions of the short arm of the human Y chromosome.
Department of Genetics, University of Cambridge, United Kingdom.
Determination of 41.2 kb of Y chromosome genomic sequence has been made from a cosmid that spans the Yp pseudoautosomal boundary and includes 18.5 kb of sequence from the patient-defined sex-determining region of the Y chromosome. An AceDB database of the sequence and the analysis data have been produced as a resource for studies of the evolution and population genetics of the Y chromosome. Comparison of the 18.5 kb from the sex determining region to the sex determining region of mouse does not locate any areas of similarity outside SRY/Sry. Indeed, no coding regions other than those previously reported can be detected anywhere in the 41 kb. The Y-specific and pseudoautosomal portions of this sequence have different repeat sequence and GC contents: this may have relevance both to the events defining the pseudoautosomal boundary and to the course of sequence evolution in the absence of recombination.
PMID: 7557997 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Incomplete masculinisation of XX subjects carrying the SRY gene on an inactive X chromosome.
Kusz K, Kotecki M, Wojda A, Szarras-Czapnik M, Latos-Bielenska A, Warenik-Szymankiewicz A, Ruszczynska-Wolska A, Jaruzelska J.
J Med Genet. 1999 Jun; 36(6):452-6.
[J Med Genet. 1999]
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Human genetic affinities for Y-chromosome P49a,f/TaqI haplotypes show strong correspondence with linguistics.
Poloni ES, Semino O, Passarino G, Santachiara-Benerecetti AS, Dupanloup I, Langaney A, Excoffier L.
Am J Hum Genet. 1997 Nov; 61(5):1015-35.
[Am J Hum Genet. 1997]
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A compositional map of human chromosome band Xq28.
De Sario A, Geigl EM, Palmieri G, D'Urso M, Bernardi G.
Proc Natl Acad Sci U S A. 1996 Feb 6; 93(3):1298-302.
[Proc Natl Acad Sci U S A. 1996]