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1: Biochem Biophys Res Commun. 1995 Jan 17;206(2):736-41.Click here to read Links

The identification of the pterin-binding domain in the nitric oxide synthase's sequence.

Uvarov VYu, Lyashenko AA.

Institute of biomedical chemistry, Moscow, Russia.

Comparative studies of primary sequences of nitric oxide synthase (NOS) and pterin-dependent enzymes has shown that the biopterin-dependent site of NOS is localized between the regions responsible for calmodulin and FMN binding. On the example of NOS from rat brain it was demonstrated that this biopterin-binding site is located in the region 750-769. Pairwise alignment of amino acids sequences of NOS from rat brain and rat xantine dehydrogenase revealed that the two proteins are 39.7% identical.

PMID: 7530005 [PubMed - indexed for MEDLINE]