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The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor.
The complete amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor has been determined from analyses of the peptides generated by cyanogen bromide, trypsin, and chymotrypsin from the naturally occurring fragments. All peptides were sequenced automatically in a spinning-cup sequenator using Polybrene to minimize extractive losses by the solvents employed thoughout the degradation cycles. The gamma-subunit, a serine protease with arginine specificity, contains 233 amino acid residues and shares sequence homology with other proteases of this family. The five disulfide bonds of the gamma-subunit are a subset of the six disulfides present in bovine trypsin, as judged by the location of the half-cystine residues in the primary structure. An N-linked carbohydrate side chain is attached to Asn-78 in at least a majority of tee gamma-molecules.
PMID: 7263706 [PubMed - indexed for MEDLINE]
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Cited by 16 PubMed Central articles
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Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
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[Dev Biol. 2007]
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Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone.
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[EMBO J. 1983]
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[Protein Sci. 1993]
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