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The nucleotide sequence of the HIS4 region of yeast.
We have determined the nucleotide sequence of the yeast HIS4 gene and its 5' and 3' flanking sequences. The protein chain has a calculated Mr-value of 87 935. Th 5' end of the HIS4 transcript maps at a position 63 bp upstream from the site of initiation of protein synthesis. The 3' end of the HIS4 transcript maps at a position approx. 118 bp after the UAG termination codon. There is no evidence for intervening sequences within the transcription unit. Functional sub-regions within the HIS4 coding frame have been identified by determining the sequence changes for various his4 mutations.
PMID: 7049842 [PubMed - indexed for MEDLINE]
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Cited by 93 PubMed Central articles
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A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strains.
Gómez-Raja J, Andaluz E, Magee B, Calderone R, Larriba G.
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[Fungal Genet Biol. 2008]
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[EMBO J. 1985]
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[EMBO J. 1983]
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