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Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes.
The human chromosomal alpha 1-antitrypsin gene has been cloned. This gene is approximately 5 kilobase pairs long and contains three intervening sequences in the peptide-coding region. DNA sequences coding for the amino and carboxyl termini of a alpha 1-antitrypsin have been identified. Human alpha 1-antitrypsin and chicken ovalbumin show significant sequences homology and belong to a common protein super-family. Yet the number, position and size of intervening sequences reveal that the two genes are dissimilar.
PMID: 6979715 [PubMed - indexed for MEDLINE]
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Cited by 25 PubMed Central articles
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Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.
Billingsley GD, Walter MA, Hammond GL, Cox DW.
Am J Hum Genet. 1993 Feb; 52(2):343-53.
[Am J Hum Genet. 1993]
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Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon.
Putt W, Ives JH, Hollyoake M, Hopkinson DA, Whitehouse DB, Edwards YH.
Biochem J. 1993 Dec 1; 296 ( Pt 2):417-22.
[Biochem J. 1993]
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Rabbit alpha-1-antiproteinase E: a novel recombinant serpin which does not inhibit proteinases.
Saito A, Sinohara H.
Biochem J. 1995 Apr 15; 307 ( Pt 2):369-75.
[Biochem J. 1995]
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