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The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase.
The nucleotide sequence of the human dihydrofolic acid reductase (DHFR) reading frame has been derived from the analysis of human DHFR cDNA. This sequence and the corresponding amino acid sequence have been compared with those available for the enzyme and its coding segment from other organisms. There is an 89% nucleotide sequence homology between the human DHFR reading frame and the mouse coding sequence. Furthermore, amino acid-sequence homologies of 74%, 81% and 89% has been found between human DHFR and chicken, bovine and mouse DHFR, respectively.
PMID: 6687716 [PubMed - indexed for MEDLINE]
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Cited by 15 PubMed Central articles
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Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance.
Sundström L, Swedberg G, Sköld O.
J Bacteriol. 1993 Mar; 175(6):1796-805.
[J Bacteriol. 1993]
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Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
Dicker AP, Waltham MC, Volkenandt M, Schweitzer BI, Otter GM, Schmid FA, Sirotnak FM, Bertino JR.
Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11797-801.
[Proc Natl Acad Sci U S A. 1993]
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Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes.
Maurer BJ, Barker PE, Masters JN, Ruddle FH, Attardi G.
Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1484-8.
[Proc Natl Acad Sci U S A. 1984]
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