-
Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
The complete nucleotide sequence of the c-fos(human) gene, the human cellular homolog of the oncogene (v-fos) of Finkel-Biskis-Jinkins murine osteosarcoma virus, has been determined. The c-fos(human) gene contains four discontinuous regions when compared with the v-fos gene. Three of the discontinuities are flanked by sequences characteristic of introns, while the fourth discontinuity is due to a deletion of 104 base pairs in the v-fos gene. As a consequence of the deletion, the predicted c-fos(human) and v-fos gene products differ at their carboxyl termini. Transcripts of 2.2 kilobases from the c-fos(human) gene have been identified in human cells. The sizes of these transcripts are in close agreement with the size expected from the nucleotide sequence after removal of introns.
PMID: 6574479 [PubMed - indexed for MEDLINE]
PMCID: PMC394004
-
Cited by 85 PubMed Central articles
-
MR contrast probes that trace gene transcripts for cerebral ischemia in live animals.
Liu CH, Huang S, Cui J, Kim YR, Farrar CT, Moskowitz MA, Rosen BR, Liu PK.
FASEB J. 2007 Sep; 21(11):3004-15. Epub 2007 May 3.
[FASEB J. 2007]
-
Members of the AP-1 family, c-Jun and c-Fos, functionally interact with JC virus early regulatory protein large T antigen.
Kim J, Woolridge S, Biffi R, Borghi E, Lassak A, Ferrante P, Amini S, Khalili K, Safak M.
J Virol. 2003 May; 77(9):5241-52.
[J Virol. 2003]
-
Regulation of human polyomavirus JC virus gene transcription by AP-1 in glial cells.
Sadowska B, Barrucco R, Khalili K, Safak M.
J Virol. 2003 Jan; 77(1):665-72.
[J Virol. 2003]
- » See all...