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Expression of active human factor VIII from recombinant DNA clones.
Wood WI,
Capon DJ,
Simonsen CC,
Eaton DL,
Gitschier J,
Keyt B,
Seeburg PH,
Smith DH,
Hollingshead P,
Wion KL, et al.
DNA clones encoding the complete 2,351 amino acid sequence for human factor VIII have been isolated and used to produce biologically active factor VIII in cultured mammalian cells. The recombinant protein corrects the clotting time of plasma from haemophiliacs and has many of the biochemical and immunological characteristics of serum-derived factor VIII.
PMID: 6438526 [PubMed - indexed for MEDLINE]
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Cited by 50 PubMed Central articles
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Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII.
Newell JL, Fay PJ.
Biochemistry. 2008 Aug 19; 47(33):8786-95. Epub 2008 Jul 22.
[Biochemistry. 2008]
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Mutation spectrum of 122 hemophilia A families from Taiwanese population by LD-PCR, DHPLC, multiplex PCR and evaluating the clinical application of HRM.
Lin SY, Su YN, Hung CC, Tsay W, Chiou SS, Chang CT, Ho HN, Lee CN.
BMC Med Genet. 2008 Jun 20; 9:53. Epub 2008 Jun 20.
[BMC Med Genet. 2008]
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Covalent genomic DNA modification patterns revealed by denaturing gradient gel blots.
Laprise SL, Gray MR.
Gene. 2007 Apr 15; 391(1-2):45-52. Epub 2006 Dec 12.
[Gene. 2007]
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