Primary structure of the Saccharomyces cerevisiae ...[Proc Natl Acad Sci U S A. 1983]

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1: Proc Natl Acad Sci U S A. 1983 May;80(9):2437-41. Links

Primary structure of the Saccharomyces cerevisiae gene for methionyl-tRNA synthetase.

Walter P, Gangloff J, Bonnet J, Boulanger Y, Ebel JP, Fasiolo F.

The sequence of a 5-kilobase DNA insert containing the structural gene for yeast cytoplasmic methionyl-tRNA synthetase has been determined and a unique open reading frame of 2,253 nucleotides encoding a polypeptide chain of 751 amino acids (Mr, 85,500) has been characterized. The data obtained on the purified enzyme (subunit size, amino acid composition, and COOH-terminal sequence) are consistent with the gene structure. The protein sequence deduced from the nucleotide sequence reveals no obvious internal repeats. This protein sequence shows a high degree of homology with that of Escherichia coli methionyl-tRNA synthetase within a region that forms the putative methionyl adenylate binding site. This strongly suggests that both proteins derive from a common ancestor.

PMID: 6341994 [PubMed - indexed for MEDLINE]

PMCID: PMC393840

Deletion analysis in the amino-terminal extension of methionyl-tRNA synthetase from Saccharomyces cerevisiae shows that a small region is important for the activity and stability of the enzyme.
J Biol Chem. 1989 Oct 15; 264(29):17126-30.

[J Biol Chem. 1989]
Homology of yeast mitochondrial leucyl-tRNA synthetase and isoleucyl- and methionyl-tRNA synthetases of Escherichia coli.
J Biol Chem. 1988 Jan 15; 263(2):850-6.

[J Biol Chem. 1988]
Cloning of the yeast methionyl-tRNA synthetase gene.
J Biol Chem. 1981 Mar 10; 256(5):2324-8.

[J Biol Chem. 1981]
ReviewUnderstanding structural relationships in proteins of unsolved three-dimensional structure.
Proteins. 1990; 7(2):99-111.

[Proteins. 1990]
ReviewStructure, function and evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code.
J Mol Evol. 1995 May; 40(5):519-30.

[J Mol Evol. 1995]
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Cited by 16 PubMed Central articles

Dominant lethality by expression of a catalytically inactive class I tRNA synthetase.
Schmidt E, Schimmel P. Proc Natl Acad Sci U S A. 1993 Aug 1; 90(15):6919-23.

[Proc Natl Acad Sci U S A. 1993]
Diversified sequences of peptide epitope for same-RNA recognition.
Kim S, Ribas de Pouplana L, Schimmel P. Proc Natl Acad Sci U S A. 1993 Nov 1; 90(21):10046-50.

[Proc Natl Acad Sci U S A. 1993]
Strategy for the mass spectrometric verification and correction of the primary structures of proteins deduced from their DNA sequences.
Gibson BW, Biemann K. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):1956-60.

[Proc Natl Acad Sci U S A. 1984]
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Primary structure of the Saccharomyces cerevisiae gene for methionyl-tRNA synthetase.

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Cited by 16 PubMed Central articles

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