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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
Ullrich A,
Coussens L,
Hayflick JS,
Dull TJ,
Gray A,
Tam AW,
Lee J,
Yarden Y,
Libermann TA,
Schlessinger J, et al.
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted v-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.
PMID: 6328312 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Structure-function analysis of nucleolin and ErbB receptors interactions.
Farin K, Di Segni A, Mor A, Pinkas-Kramarski R.
PLoS One. 2009 Jul 3; 4(7):e6128. Epub 2009 Jul 3.
[PLoS One. 2009]
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Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, et al.
Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5082-7. Epub 2009 Mar 16.
[Proc Natl Acad Sci U S A. 2009]
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Identification of nucleolin as new ErbB receptors- interacting protein.
Di Segni A, Farin K, Pinkas-Kramarski R.
PLoS One. 2008 Jun 4; 3(6):e2310. Epub 2008 Jun 4.
[PLoS One. 2008]
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