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Molecular cloning of two distinct renin genes from the DBA/2 mouse.
We report the molecular cloning of cDNA copies of DBA/2 mouse submaxillary gland (SMG) renin mRNA, which were used to probe Southern transfers of mouse genomic DNA. The results suggested either that there is a single renin gene containing a large intron in that part of the gene corresponding to the probe, or that there are two distinct renin genes. We have shown that the latter is the case by cloning and isolating two similar but distinct renin genes from DBA/2 mouse DNA. Restriction maps of the regions containing the two renin genes are presented, together with nucleotide sequence data locating a complete exon coding for amino acids 268-315 of mouse SMG renin.
PMID: 6327270 [PubMed - indexed for MEDLINE]
PMCID: PMC553232
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Cited by 20 PubMed Central articles
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Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression.
Horiuchi M, Pratt RE, Nakamura N, Dzau VJ.
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[J Clin Invest. 1993]
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In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer.
Yamada T, Horiuchi M, Morishita R, Zhang L, Pratt RE, Dzau VJ.
J Clin Invest. 1995 Sep; 96(3):1230-7.
[J Clin Invest. 1995]
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Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2 mouse sub-maxillary glands.
Windass JD, Mullins JJ, Beecroft LJ, George H, Meacock PA, Williams BR, Brammar WJ.
Nucleic Acids Res. 1984 Feb 10; 12(3):1361-76.
[Nucleic Acids Res. 1984]
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