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Structure of a human gastrin gene.
A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptide, from the region coding for the major amino-terminal portion of the gastrin precursor. The 5' flanking region of the gene contains the conserved sequences, T-A-T-A-A and G-A-C-T-C-A-T-A-T, in positions similar to those of other eukaryotic genes.
PMID: 6322186 [PubMed - indexed for MEDLINE]
PMCID: PMC344765
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Cited by 11 PubMed Central articles
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Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
Stepan VM, Sawada M, Todisco A, Dickinson CJ.
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[Mol Med. 1999]
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Processing and proliferative effects of human progastrin in transgenic mice.
Wang TC, Koh TJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Dockray GJ.
J Clin Invest. 1996 Oct 15; 98(8):1918-29.
[J Clin Invest. 1996]
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Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.
Wang TC, Bonner-Weir S, Oates PS, Chulak M, Simon B, Merlino GT, Schmidt EV, Brand SJ.
J Clin Invest. 1993 Sep; 92(3):1349-56.
[J Clin Invest. 1993]
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