Gene product of v-fgr onc: hybrid protein containi...[Science. 1984]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Science. 1984 Jan 6;223(4631):63-6. Links

Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.

Naharro G, Robbins KC, Reddy EP.

The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.

PMID: 6318314 [PubMed - indexed for MEDLINE]

Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes.
J Virol. 1983 Sep; 47(3):611-9.

[J Virol. 1983]
The TP1 isolate of feline sarcoma virus encodes a fgr-related oncogene lacking gamma actin sequences.
Oncogene. 1989 Mar; 4(3):363-72.

[Oncogene. 1989]
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes.
Cell. 1982 Oct; 30(3):775-85.

[Cell. 1982]
ReviewNakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family.
Princess Takamatsu Symp. 1986; 17:11-20.

[Princess Takamatsu Symp. 1986]
ReviewTwo new retroviral onc genes, sea and jun.
Princess Takamatsu Symp. 1986; 17:23-30.

[Princess Takamatsu Symp. 1986]
» See reviews... | » See all...

Cited by 63 PubMed Central articles

Review3' junctions of oncogene-virus sequences and the mechanisms for formation of highly oncogenic retroviruses.
Zhang J, Temin HM. J Virol. 1993 Apr; 67(4):1747-51.

[J Virol. 1993]
Avian erythroblastosis virus E26: only one (myb) of two cell-derived coding regions is necessary for oncogenicity.
Wu Y, Duesberg P. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):4039-43.

[Proc Natl Acad Sci U S A. 1994]
The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage.
Hatakeyama S, Iwabuchi K, Ogasawara K, Good RA, Onoé K. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3458-62.

[Proc Natl Acad Sci U S A. 1994]
» See all...

Recent Activity

Clear Turn Off Turn On

Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-spe...Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.

Related articles

Cited by 63 PubMed Central articles

Recent Activity