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Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene.
The nucleotide sequence of an 8658-base-pair human genomic DNA segment containing the entire corticotropin-beta-lipotropin precursor gene has been determined, and some sequence features of the gene and its flanking regions have been analysed. The gene is composed of 7665 base pairs including two introns of 3708 and 2886 base pairs. Comparison of the 5'-flanking sequences of the human, bovine and mouse corticotropin-beta-lipotropin precursor genes reveals the presence of a highly conserved region, which contains sequences of 14-15 base pairs homologous with sequences located upstream of the mRNA start site of other glucocorticoid-regulated genes.
PMID: 6314261 [PubMed - indexed for MEDLINE]
PMCID: PMC326418
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Cited by 11 PubMed Central articles
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Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.
Stratakis CA, Carney JA, Lin JP, Papanicolaou DA, Karl M, Kastner DL, Pras E, Chrousos GP.
J Clin Invest. 1996 Feb 1; 97(3):699-705.
[J Clin Invest. 1996]
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"Cryptic" repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic: analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (TBP) genes.
Gostout B, Liu Q, Sommer SS.
Am J Hum Genet. 1993 Jun; 52(6):1182-90.
[Am J Hum Genet. 1993]
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DNA methylation in the Alu sequences of diploid and haploid primary human cells.
Kochanek S, Renz D, Doerfler W.
EMBO J. 1993 Mar; 12(3):1141-51.
[EMBO J. 1993]
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