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The genome-linked protein of picornaviruses. VII. Genetic mapping of poliovirus VPg by protein and RNA sequence studies.
The poliovirus genome-linked protein (VPg) has been subjected to radiochemical microsequence analysis. Sequence studies of virion RNA by a modification of Sanger's dideoxy method have revealed a base sequence corresponding to the amino acid analysis. This result proves that VPg is virus-encoded. The RNA sequence has allowed us to predict the total amino acid sequence of VPg and part of its precursor. VPg is, at most, 27 amino acids long. It maps within the 3' terminal segment of the viral genome that encodes the precursor polypeptide NCVP1b for the virus-specific RNA polymerase NCVP4.
PMID: 6250717 [PubMed - indexed for MEDLINE]
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Cited by 17 PubMed Central articles
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Determination of the Proteolytic Processing Sites in the Polyprotein Encoded by the Bottom-Component RNA of Cowpea Mosaic Virus.
Wellink J, Rezelman G, Goldbach R, Beyreuther K.
J Virol. 1986 Jul; 59(1):50-58.
[J Virol. 1986]
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Expression of the Bottom-Component RNA of Cowpea Mosaic Virus: Evidence that the 60-Kilodalton VPg Precursor Is Cleaved into Single VPg and a 58-Kilodalton Polypeptide.
Goldbach R, Rezelman G, Zabel P, van Kammen A.
J Virol. 1982 May; 42(2):630-635.
[J Virol. 1982]
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Antibodies Against the Genome-Linked Protein VPg of Cowpea Mosaic Virus Recognize a 60,000-Dalton Precursor Polypeptide.
Zabel P, Moerman M, van Straaten F, Goldbach R, van Kammen A.
J Virol. 1982 Mar; 41(3):1083-1088.
[J Virol. 1982]
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