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Genetic variation in the human insulin gene.
Four recombinant lambda phages containing nucleotide sequences complementary to a cloned human preproinsulin DNA probe have been isolated from human DNA. Restriction analyses in conjunction with Southern hybridizations reveal two types of gene sequences. One isolate of each type was subjected to complete nucleotide sequence determination. The sequences contain the entire preproinsulin messenger RNA region, two intervening sequence. 260 nucleotides upstream from the messenger RNA capping site, and 35 nucleotides beyond the polyadenylate attachment site. Our results strongly suggest that these two gene types are allelic variants of a single insulin gene.
PMID: 6248962 [PubMed - indexed for MEDLINE]
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Cited by 25 PubMed Central articles
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Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation.
Mein CA, Barratt BJ, Dunn MG, Siegmund T, Smith AN, Esposito L, Nutland S, Stevens HE, Wilson AJ, Phillips MS, et al.
Genome Res. 2000 Mar; 10(3):330-43.
[Genome Res. 2000]
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Codon catalog usage is a genome strategy modulated for gene expressivity.
Grantham R, Gautier C, Gouy M, Jacobzone M, Mercier R.
Nucleic Acids Res. 1981 Jan 10; 9(1):r43-74.
[Nucleic Acids Res. 1981]
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Asymmetrical distribution of CpG in an 'average' mammalian gene.
McClelland M, Ivarie R.
Nucleic Acids Res. 1982 Dec 11; 10(23):7865-77.
[Nucleic Acids Res. 1982]
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