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Sequence of the human insulin gene.
The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.
PMID: 6243748 [PubMed - indexed for MEDLINE]
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Cited by 66 PubMed Central articles
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Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).
Akhter Hossain M, Bathgate RA, Kong CK, Shabanpoor F, Zhang S, Haugaard-Jönsson LM, Rosengren KJ, Tregear GW, Wade JD.
Chembiochem. 2008 Jul 21; 9(11):1816-22.
[Chembiochem. 2008]
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Induction of insulin secretion in engineered liver cells by nitric oxide.
Muniappan L, Ozcan S.
BMC Physiol. 2007 Oct 17; 7:11. Epub 2007 Oct 17.
[BMC Physiol. 2007]
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Insulin gene mutations as a cause of permanent neonatal diabetes.
Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, et al.
Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15040-4. Epub 2007 Sep 12.
[Proc Natl Acad Sci U S A. 2007]
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