-
DNA sequence of a major human leukocyte interferon gene.
The gene for human leukocyte interferon alpha 2 (designated either LeIF A or HuIFN-alpha 2) has been isolated from a human genome library. The DNA sequence of this gene demonstrates that it lacks introns. The 3' noncoding sequences of the IFN-alpha 2 gene correspond to two types of IFN-alpha 2 cDNA clones we have isolated that have alternate sites of polyadenylylation. A comparison of seven human IFN-alpha sequences shows that they are homologous in the 5' flanking region and contain identical "TATA box" sequences. The recombinant lambda clone containing the IFN-alpha 2 gene also contains two copies of the "Alu family" repeat sequence.
PMID: 6170983 [PubMed - indexed for MEDLINE]
PMCID: PMC348760
-
Cited by 17 PubMed Central articles
-
Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio.
Altmann SM, Mellon MT, Distel DL, Kim CH.
J Virol. 2003 Feb; 77(3):1992-2002.
[J Virol. 2003]
-
Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.
Jolly DJ, Esty AC, Bernard HU, Friedmann T.
Proc Natl Acad Sci U S A. 1982 Aug; 79(16):5038-41.
[Proc Natl Acad Sci U S A. 1982]
-
The chromosomal location of mouse interferon alpha genes.
Lovett M, Cox DR, Yee D, Boll W, Weissmann C, Epstein CJ, Epstein LB.
EMBO J. 1984 Jul; 3(7):1643-6.
[EMBO J. 1984]
- » See all...