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The complete nucleotide sequence of a common cold virus: human rhinovirus 14.
The complete nucleotide sequence of the single-stranded RNA genome of human rhinovirus 14, one of the causative agents of the common cold, has been determined from cDNA cloned in E. coli. The genome is typical of the picornaviridae family, comprising a 5' non-coding region of 624 nucleotides, a long open reading frame of 6537 nucleotides (90.8% of the genome) and a 3' non-coding region of 47 nucleotides. Comparison of the nucleotide sequence and the predicted amino acid sequence with those of the polioviruses reveals a surprising degree of homology which may allow recognition of regions of antigenic importance and prediction of the virus polyprotein cleavage sites. The results presented here imply a closer genetic relationship between the rhinovirus and enterovirus genera than previously suspected.
PMID: 6093056 [PubMed - indexed for MEDLINE]
PMCID: PMC320205
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Cited by 57 PubMed Central articles
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A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants.
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[PLoS One. 2007]
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In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.
Binford SL, Weady PT, Maldonado F, Brothers MA, Matthews DA, Patick AK.
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[Antimicrob Agents Chemother. 2007]
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Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children.
Lau SK, Yip CC, Tsoi HW, Lee RA, So LY, Lau YL, Chan KH, Woo PC, Yuen KY.
J Clin Microbiol. 2007 Nov; 45(11):3655-64. Epub 2007 Sep 5.
[J Clin Microbiol. 2007]
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