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Structure of the chromosomal gene for human serum prealbumin.
The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3'-flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found in the 5'-flanking region and introns.
PMID: 4054629 [PubMed - indexed for MEDLINE]
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Cited by 10 PubMed Central articles
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Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met.
Takaoka Y, Ohta M, Miyakawa K, Nakamura O, Suzuki M, Takahashi K, Yamamura K, Sakaki Y.
Am J Pathol. 2004 Jan; 164(1):337-45.
[Am J Pathol. 2004]
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Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro.
Sousa MM, Fernandes R, Palha JA, Taboada A, Vieira P, Saraiva MJ.
Am J Pathol. 2002 Nov; 161(5):1935-48.
[Am J Pathol. 2002]
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A new isoleucine substitution of Val-20 in transthyretin tetramers selectively impairs dimer-dimer contacts and causes systemic amyloidosis.
Jenne DE, Denzel K, Blätzinger P, Winter P, Obermaier B, Linke RP, Altland K.
Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6302-7.
[Proc Natl Acad Sci U S A. 1996]
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