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Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.
The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
PMID: 4023707 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replication.
Song BH, Yun SI, Choi YJ, Kim JM, Lee CH, Lee YM.
RNA. 2008 Sep; 14(9):1791-813. Epub 2008 Jul 30.
[RNA. 2008]
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Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.
Mueller NH, Pattabiraman N, Ansarah-Sobrinho C, Viswanathan P, Pierson TC, Padmanabhan R.
Antimicrob Agents Chemother. 2008 Sep; 52(9):3385-93. Epub 2008 Jul 7.
[Antimicrob Agents Chemother. 2008]
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E protein domain III determinants of yellow fever virus 17D vaccine strain enhance binding to glycosaminoglycans, impede virus spread, and attenuate virulence.
Lee E, Lobigs M.
J Virol. 2008 Jun; 82(12):6024-33. Epub 2008 Apr 9.
[J Virol. 2008]
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