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Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme.
The complete covalent structure of the 331 amino acids of mouse lactate dehydrogenase (LDH) A4 isozyme has been determined by sequence analyses of both the protein and the genomic DNA. The mouse LDH-A gene spans a length of at least 7000 bases from the translation initiation codon ATG to the end of the 3' untranslated region, and it contains six introns that interrupt the protein-coding sequence. The relationships between the exon-intron organization of LDH-A gene and the structural-functional domains of the protein are discussed.
PMID: 3996406 [PubMed - indexed for MEDLINE]
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Cited by 14 PubMed Central articles
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Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat.
Tsuji S, Qureshi MA, Hou EW, Fitch WM, Li SS.
Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9392-6.
[Proc Natl Acad Sci U S A. 1994]
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Identification of the mouse low-salt-eluting single-stranded DNA-binding protein as a mammalian lactate dehydrogenase-A isoenzyme.
Sharief FS, Wilson SH, Li SS.
Biochem J. 1986 Feb 1; 233(3):913-6.
[Biochem J. 1986]
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Molecular nature of spontaneous mutations in mouse lactate dehydrogenase-A processed pseudogenes.
Fukasawa KM, Tanimura M, Sakai I, Sharief FS, Chung FZ, Li SS.
Genetics. 1987 Jan; 115(1):177-84.
[Genetics. 1987]
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