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Hepatitis B virus genes and their expression in E. coli.
A composite DNA sequence of regions of hepatitis B virus, determined from a series of recombinant plasmids, reveals the genes for the surface antigen and the core antigen of the virus. The sequence of the core antigen shows it to be a DNA binding protein. The core antigen gene is expressed in Escherichia coli and when injected into rabbits the bacterial product induces antibodies which react with core antigen isolated from human sources.
PMID: 399329 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules.
Stachowski J, Barth C, Pollok M, Michałkiewicz J, Madaliński K, Maciejewski J, Baldamis CA.
Mediators Inflamm. 1995; 4(1):49-54.
[Mediators Inflamm. 1995]
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Hepatitis B virus replication is associated with an HBx-dependent mitochondrion-regulated increase in cytosolic calcium levels.
McClain SL, Clippinger AJ, Lizzano R, Bouchard MJ.
J Virol. 2007 Nov; 81(21):12061-5. Epub 2007 Aug 15.
[J Virol. 2007]
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A structural model for maturation of the hepatitis B virus core.
Roseman AM, Berriman JA, Wynne SA, Butler PJ, Crowther RA.
Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44):15821-6. Epub 2005 Oct 24.
[Proc Natl Acad Sci U S A. 2005]
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