A novel class of human type I interferons. [Nucleic Acids Res. 1985]

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1: Nucleic Acids Res. 1985 Jul 11;13(13):4739-49. Links

A novel class of human type I interferons.

Hauptmann R, Swetly P.

The screening of a cDNA library prepared from mRNA of Sendai virus induced Namalwa (human Burkitt's lymphoma) cells, using a human IFN-alpha 2 DNA probe under conditions of low stringency, identified two weakly hybridizing clones containing sequences related to, but discernably different from those of the IFN-alpha class. Sequence and hybridization analysis of these cDNAs as well as expression in E. coli provided evidence that they encode proteins which have the characteristics of IFN type I but which are sufficiently diverged in sequence from both IFN-alpha s and IFN-beta to suggest that they are representatives of a new and distinct class of interferons named interferon-omega. Hybridization of these sequences to genomic DNA reveals that this class contains at least four members.

PMID: 3895159 [PubMed - indexed for MEDLINE]

PMCID: PMC321823

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A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes.
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Cited by 2 PubMed Central articles

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