Close relationship of the major excreted protein o...[Cancer Res. 1986]

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1: Cancer Res. 1986 Sep;46(9):4590-3. Links

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

Denhardt DT, Hamilton RT, Parfett CL, Edwards DR, St Pierre R, Waterhouse P, Nilsen-Hamilton M.

Complementary DNA clones corresponding to 638 nucleotides of the messenger RNA encoding the major portion of murine major excreted protein have been isolated and sequenced. The amino acid sequence of a part of the murine major excreted protein deduced from the DNA sequence reveals substantial and significant homology with the cysteine proteases actinidin, rat cathepsin H, and papain. Since the amount of murine major excreted protein secreted by cultured cells is often enhanced by transformation, it is implicated in oncogenic phenomena and may play a role in the metastatic process by virtue of its proteolytic activity.

PMID: 3755373 [PubMed - indexed for MEDLINE]

Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.
Arch Biochem Biophys. 1990 Dec; 283(2):447-57.

[Arch Biochem Biophys. 1990]
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.
J Clin Invest. 1988 May; 81(5):1621-9.

[J Clin Invest. 1988]
Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.
Mol Cell Biol. 1988 Aug; 8(8):3316-21.

[Mol Cell Biol. 1988]
Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
Biochem J. 1987 Sep 15; 246(3):731-5.

[Biochem J. 1987]
ReviewThe role of cathepsin L in malignant transformation.
Semin Cancer Biol. 1990 Apr; 1(2):127-36.

[Semin Cancer Biol. 1990]
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Cited by 7 PubMed Central articles

Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
Troen BR, Gal S, Gottesman MM. Biochem J. 1987 Sep 15; 246(3):731-5.

[Biochem J. 1987]
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L.
Mason RW, Gal S, Gottesman MM. Biochem J. 1987 Dec 1; 248(2):449-54.

[Biochem J. 1987]
Isolation and sequence of a cDNA for human pro-(cathepsin L).
Gal S, Gottesman MM. Biochem J. 1988 Jul 1; 253(1):303-6.

[Biochem J. 1988]
» See all...

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Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

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Cited by 7 PubMed Central articles

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