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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
PMID: 3754034 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Association of estrogen receptor alpha gene polymorphisms with cytokine genes expression in systemic lupus erythematosus.
Lu ZM, Wang ZE, Liu YQ, Wu CX, Wang CY, Zhang BC, Shao S, Jiao YL, Che ZX, Chen ZJ, et al.
Croat Med J. 2009 Apr; 50(2):117-23.
[Croat Med J. 2009]
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Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
Nott SL, Huang Y, Fluharty BR, Sokolov AM, Huang M, Cox C, Muyan M.
Curr Pharmacogenomics Person Med. 2008 Dec 1; 6(4):239-259.
[Curr Pharmacogenomics Person Med. 2008]
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Physiology of membrane oestrogen receptor signalling in reproduction.
Micevych P, Kuo J, Christensen A.
J Neuroendocrinol. 2009 Mar; 21(4):249-56.
[J Neuroendocrinol. 2009]
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